Articles Tagged With:
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Markers and Mechanisms of Chronic Fatigue Following Mononucleosis
Chronic disabling fatigue affects up to 2% of adolescents and often follows Epstein-Barr virus-related mononucleosis. No clinically significant infectious, immune, neuroendocrine, or autonomic biomarker or pathophysiologic mechanism has been identified to differentiate those with mononucleosis who go on to develop chronic fatigue from those who recover.
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Cefazolin and Ertapenem as Salvage Therapy in Methicillin-Susceptible Staphylococcus aureus Bacteremia
Cefazolin (CZ) and ertapenem combination therapy was successfully used to salvage 11 cases of persistent methicillin-susceptible Staphylococcus aureus bacteremia. Modest in vitro synergy between CZ and ertapenem was demonstrated on testing of six clinical isolates, but in vivo activity appeared more potent in an animal model than as predicted by in vitro activity.
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Fulminant Clostridioides difficile Infection: Hold the IV Metronidazole?
The combination of oral vancomycin and intravenous metronidazole is not superior to vancomycin alone in the treatment of fulminant infection due to Clostridioides difficile.
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What Is the Risk of Joint Prosthesis Infection Resulting From Bacteremia?
The risk of periprosthetic joint infection resulting from bacteremia depends on the organism.
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Preventing Readmissions and Optimizing Outcomes for Staphylococcus aureus Bacteremia: Still a Long Journey Ahead
Using a population-based database, investigators found that the rate of readmission within 30 days following hospitalization for S. aureus bacteremia was high (22%) and resulted in high cost to the healthcare system.
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CDC: Fight Against AIDS at Key Inflection Point
CDC officials updated an ambitious plan to essentially end the AIDS epidemic in the United States in the next decade. While taking an overall national approach, the plan — part of a collaboration between the CDC and other federal agencies — would target specific geographic areas and at-risk populations.
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Mass Flu Vaccinations Serve as Emergency Drills
Infection preventionists may one day be faced with a pandemic flu or the release of a bioterrorism agent that calls for mass vaccinations or post-exposure prophylaxis of healthcare workers. One novel way to prepare now is to stage annual flu vaccinations as an emergency drill.
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Human Factors: Drug Stewardship in the Emergency Department
Broadly classified as ergonomics in much of the world, human factors engineering ultimately may lead to changes in practices and behaviors entrenched in healthcare that endanger patients with infections and other harms.
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C. auris: A Bad Bug With a Worst-Case Scenario
Imagine if a common healthcare-associated infection became impossible to treat. The nightmare scenario public health officials are contemplating is that an emerging strain of multidrug-resistant Candida auris will displace treatable strains of Candida, which are already a leading cause of bloodstream infections.
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Murderers’ Row: Resistant to Drugs, Threats to Humans
In a recently published report on antibiotic threats in the United States, the Centers for Disease Control and Prevention classified pathogens as urgent, serious, concerning, or put them on a “watch list.”